Piperazine intermediates are a privileged class of nitrogen-containing heterocyclic building blocks, valued for their structural versatility and excellent drug-like properties. The piperazine ring acts as a key linker and solubilizing group, significantly improving the pharmacokinetic profiles of final molecules. Our portfolio includes a diverse range of high-purity, n-substituted piperazine derivatives, essential for developing pharmaceuticals in areas such as central nervous system (cns) disorders, antipsychotics, and antibiotics. We provide reliable supply, consistent quality, and expert custom synthesis to meet your specific r&d and manufacturing needs.
| Name | CAS Number | Molecular Formula | Chemical Structure |
| 1-(4-Nitrophenyl)piperazine | 6269-89-2 | C10H13N3O2 |  |
| Piperazine, 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-pyridinyl]- | 2096330-62-8 | C16H26BN3O2 | ![Piperazine, 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-pyridinyl]-](/uploads/image/20260428/piperazine-1-methyl-4-3-4-4-5-5-tetramethyl-1-3-2-dioxaborolan-2-yl-4-pyridinyl-2096330-62-8.png "Piperazine, 1-methyl-4-[3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-pyridinyl]-") |
| Piperazine, 1-[2-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]ethyl]-4-methyl- | 1007071-72-8 | C16H21FN4 | ![Piperazine, 1-[2-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]ethyl]-4-methyl-](/uploads/image/20260428/piperazine-1-2-3-4-fluorophenyl-1h-pyrazol-4-yl-ethyl-4-methyl-1007071-72-8.png "Piperazine, 1-[2-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]ethyl]-4-methyl-") |
| 1-N,4-N-bis(4-methoxyphenyl)piperazine-1,4-dicarbothioamide | 485356-33-0 | C20H24N4O2S2 |  |
| 1-Benzyl-4-(3-fluoro-2-(trifluoromethyl)-phenyl)piperazine | 1707581-18-7 | C18H18F4N2 |  |
Piperazine intermediates are valued as privileged scaffolds in medicinal chemistry. Their primary mechanism is to act as a versatile, tunable linker or spacer between different molecular fragments. The six-membered ring's unique conformational flexibility and the presence of two nitrogen atoms allow it to fine-tune molecular geometry, solubility, and pharmacokinetic properties. This enables critical interactions with biological targets, such as receptors and enzymes. As a result, they are indispensable for optimizing the drug-likeness and efficacy of final compounds, making them core components in central nervous system (CNS) drugs, antipsychotics, antimicrobials, and anticancer agents.
Piperazine Intermediates
Piperazine intermediates are key precursors for synthesizing antipsychotic drugs like fluphenazine and trifluoperazine. The piperazine ring acts as a crucial structural scaffold that enhances binding affinity to dopamine and serotonin receptors in the brain.
Piperazine Intermediates
Piperazine intermediates are essential building blocks for fluoroquinolone antibiotics, including norfloxacin and ciproflazine. They contribute to the core structure that enables these drugs to inhibit bacterial DNA gyrase and topoisomerase IV effectively.
Piperazine Intermediates
Piperazine intermediates serve as vital precursors for antihistamines and calcium channel blockers such as cinnarizine and flunarizine. The piperazine moiety improves solubility and pharmacokinetics, allowing for better blood-brain barrier penetration and vascular effects.
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