Pyridine boronic acids are a vital subclass of boronic acid derivatives where the boron functional group is attached to a pyridine ring. This integration of a boron handle with a nitrogen-containing heterocycle makes them exceptionally valuable in medicinal chemistry and materials science. They are crucial coupling partners in suzuki-miyaura reactions for constructing biaryl and heterobiaryl systems, which are core scaffolds in many pharmaceuticals, such as kinase inhibitors. We offer a diverse portfolio with consistent high purity and reliable supply to accelerate your drug discovery and development projects. Custom synthesis is available for specialized derivatives.
| Name | CAS Number | Molecular Formula | Chemical Structure |
| Pyridine-3-boronic acid (3-Pyridylboronic acid) | 1692-25-7 | C₅H₆BNO₂ |  |
| Pyridine-4-boronic acid (4-Pyridylboronic acid) | 1692-15-5 | C₅H₆BNO₂ |  |
| 2-Methoxypyridine-3-boronic acid | 163105-90-6 | C₆H₈BNO₃ |  |
| 4-Methylpyridine-3-boronic acid | 148546-82-1 | C₆H₈BNO₂ |  |
| 5-Cyanopyridine-3-boronic acid | 497147-93-0 | C₆H₅BN₂O₂ |  |
Pyridine boronic acids are highly effective coupling partners in Suzuki-Miyaura cross-coupling reactions. Their mechanism relies on a palladium-catalyzed cycle. The electron-deficient pyridine ring, combined with the boron functional group, facilitates efficient transmetalation—a key step where the organoboron species transfers its organic group to the palladium catalyst. This enables the reliable formation of carbon-carbon bonds, specifically creating biaryl structures that connect the pyridine ring to other aromatic systems. Their unique structure is crucial for synthesizing nitrogen-containing heterocycles, which are privileged scaffolds in pharmaceuticals, such as kinase inhibitors, making them indispensable for constructing complex drug candidates.
Pyridine Boronic Acids
Pyridine boronic acids are vital precursors for synthesizing tyrosine kinase inhibitors (TKIs), a major class of targeted cancer therapies. Their structure enables efficient cross-coupling to build the core pharmacophore essential for blocking specific cancer-driving enzymes.
Pyridine Boronic Acids
Pyridine boronic acids are key intermediates in Suzuki-Miyaura cross-coupling reactions, widely used to construct complex drug molecules. This allows for the modular assembly of diverse pharmaceutical scaffolds, including those for antiviral and anti-inflammatory agents.
Pyridine Boronic Acids
Pyridine boronic acids serve as crucial building blocks for central nervous system (CNS) drugs and antibiotics. The pyridine ring contributes to binding affinity and solubility, while the boronic acid group facilitates precise molecular construction.
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